Clark saves a man who in gratitude decides to help Clark in return…by using his ability to turn invisible and his skill as a hitman to kill Lex so Clark can reunite with Lana. And Clark and Lana finally square off about Lana’s new relationship.
Haley argues about her wedding dress with Brooke during the rehearsal dinner; Karen and Lucas arrive back in town; and Peyton is surprised by what she finds.
House treats a 15 year old faith healer, while Wilson feels left out when he finds out House isn’t planning on inviting him to his weekly poker game.
Michael must get the key to the infirmary and enlist the help of an old face, while Lincoln learns the identity of his kidnapper and another inmate learns of the escape.
Lionel is taken hostage by a masked man who forces him to play elaborate games for the prize of staying alive. Martha goes to confront Lionel after Clark tells her Lionel knows his secret and becomes a part of the game herself, fighting for her life.
Nathan deals with a player who is a rival both on and off the court; Brooke and Mouth look to get even with Rachel; Dan has a run-in with Cooper; and Peyton comes to a major decision.
House has to work fast when a woman comes in with a life-threatening case of insomnia. Meanwhile Cameron is angry at Foreman for stealing an article she worked on.
In an effort to recreate the missing piece of the tattoo, Michael gets transferred to the psych ward, seeking the help of Haywire. T-Bag and C-Note have to join forces.
Clark befriends a little girl who has the ability to telekinetically shatter glass, then comes to her aid when it’s believed she killed her mother in a brutal stabbing attack. Meanwhile Lex and Lana grow closer together and Chloe finds out about it.
Rose is surprisingly and vehemently opposed to Bernard’s plan to create an S.O.S. signal; romantic sparks are rekindled between Jack and Kate when they trek into the jungle to propose a “trade” with “The Others”; and Locke begins to question his faith in the island.
